The full transverse coherence of the LCLS laser will allow single particles to be imaged at high resolution while the short pulse duration will limit radiation damage during the measurement. The instrument will allow imaging of biological samples beyond the damage limit that cannot be overcome with synchrotron sources.

Admittedly, I’m not sure, from the description of the source, whether they can use the transverse coherence of their x-ray source to get a hologram of a single molecule.

- Excellent 2-Dimensional heat conductor. (think about it for a while )

- By changing the shape and size of the sheet of graphene you change how it interacts with the EM spectrum.

- Conceptually simple way to make a very wide variety of 3 -D shapes : Cut – Stack – (Mechanically) Lock in Place standard sheets of graphene [or Stamp - Stack -(chemically) Stick standard sheets of graphene together.]

The TEAM microscope, though, provides far more resolution than is necessary (or even desirable) for tissue studies. The problems with 3D neural mapping, as I understand them, are chiefly those of sample preparation, high-throughput imaging, and software for image processing, alignment, and inference of 3D structures.

I would expect the appropriate resolution to be in the nanometer range, which makes the volume elements imaged larger by >10³. Where atomic resolution would be appropriate, for example, in determining protein structures, it turns out to be unavailable: the electron beam destroys the sample before enough data can be collected to make a useful inference about atomic (or even near-atomic) structure. Successful imaging is limited to larger volume elements, or to robust, non-biological materials. (Feynman had hoped for a larger contribution to biology.)
—————
Update: I just came across a link to a new and very relevant article in PLoS Computational Biology: “A Proposal for a Coordinated Effort for the Determination of Brainwide Neuroanatomical Connectivity in Model Organisms at a Mesoscopic Scale”. They propose to develop mesosopic maps because “for complex vertebrate brains it is not currently technologically feasible to determine brainwide connectivity at the level of individual synapses”.