Faster, more reliable fabrication of atomically precise products:
We demonstrate that, at constant temperature, hundreds of DNA strands can cooperatively fold a long template DNA strand within minutes into complex nanoscale objects….Folding at optimized constant temperatures enabled the rapid production of three-dimensional DNA objects with yields that approached 100%. The results point to similarities with protein folding in spite of chemical and structural differences. The possibility for rapid and high-yield assembly will enable DNA nanotechnology for practical applications.
…prospects for the hierarchical assembly (8, 26–28) of larger objects are opened, where a high yield of well-folded building blocks is one important prerequisite.
Image to the right: Electron micrograph of folded DNA objects produced by warming and cooling a solution containing designed DNA strands (typical quantities made: billions). One of many different structures designed and demonstrated by the authors in the Physics Department at the Technische Universität München.
(Black scale bars, 20 nm; white scale bar, 200 nm)