Nanoscience

It’s official: “Nano” now means materials

November 11, 2013

From “About this journal”: Nano Research…focuses on all aspects of nanoscience and nanotechnology…ranging from…materials to…materials.”[edited for maximal snark] Here’s the full paragraph: Nano Research is a peer-reviewed, international and interdisciplinary research journal that focuses on all aspects of nanoscience and nanotechnology. Submissions are solicited in all topical areas, ranging from basic aspects of the science […]

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Atomic precision or atomically precise design?

November 6, 2013

Why is foldamer engineering a key to unlocking the potential of atomically precise engineering? The reason is that foldamers (polypeptides, polypeptoids, nucleic acids, and the like) form a modular construction kit for a vast, combinatorial range of structures, while most other atomically precise constructs do not. Consider a recent surprising discovery in the world of […]

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Serverification of molecular engineering tools

November 3, 2013

If you’re interested in RosettaDesign (see Learning practical atomically precise fabrication and Further notes…), you might want to look at this PLOS ONE paper: Serverification of Molecular Modeling Applications: The Rosetta Online Server That Includes Everyone (ROSIE) …This paper describes the ROSIE server infrastructure, a step-by-step ‘serverification’ protocol for use by Rosetta developers, and the […]

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Further notes on Rosetta, RosettaDesign
— and Rosie

October 31, 2013

In “Learning practical atomically precise fabrication”, I blogged a paper on the Rosetta software suite for protein modeling and design (you might want to skip quickly to page 2993, “Protein Design”). I’ve also done a guest post, “Macromolecular Modeling for Molecular Systems Engineering” for the Rosetta Design Group’s blog, and that post offers a deeper […]

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Learning practical atomically precise fabrication

October 30, 2013

If you’d like to learn about (and perhaps help advance) the state of the art in fabricating intricate, nanoscale, atomically precise objects, you might want to examine this paper: Practically Useful: What the ROSETTA Protein Modeling Suite Can Do for You (open-access pdf). The materials are peptide polymers, a diverse class of materials that can […]

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Nobel Prize for Computational Chemistry

October 9, 2013

Michael Levitt, Martin Karplus, and Arieh Warshel have been awarded the Nobel Prize in chemistry for their contributions to computational methods for molecular simulation. These are the methods that tell us how atomically precise covalent structures can serve as high-performance nanomachines, which will provide the basis for advanced high-throughput atomically precise manufacturing. (BBC)

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Beilstein Symposium 2012:
Molecular Engineering and Control

May 23, 2012

Last week I gave the opening talk at the 10th Beilstein Symposium in Prien, Germany, a meeting focused on molecular engineering and control. This is a small, invitational meeting series — the kind where about half the participants are also speakers. What makes the Beilstein Symposiums unusual is their cross-disciplinary orientation. At this year’s meeting, […]

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Peptoid technology for molecular nanosystems — My review is now online

November 7, 2011

My invited review “Peptoids at the 7th Summit: Toward Macromolecular Systems Engineering” [pdf] kicks off the peptoid special issue of Biopolymers: Peptide Science. Astoundingly, all the papers are open access. Here’s the abstract: Peptoids at the 7th Summit: Toward Macromolecular Systems Engineering Methods for facile synthesis of extraordinarily diverse peptide-like oligomers have placed peptoids at […]

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An advance in atomically precise
building-block assembly

May 27, 2011

A paper in Science reports a design method that substantially advances the macromolecular technology base for building atomically precise nanosystems. Background: foldamer engineering As many readers know, biology shows an effective way build large, intricate, atomically precise systems: Use covalent chemistry to build chains of small building blocks, and design these chains to fold into […]

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Polyoxometalate papers

May 3, 2011

Background: polyoxometalate nanostructures are cool (more here). Lee Cronin sent me a pdf of the polyoxometalate paper I discussed in my previous post, and he notes that readers can download it here, with other papers on his group’s website here. The Israel Journal of Chemistry has a new special issue, “Frontiers in Metal Oxide Cluster […]

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Across the blood-brain barrier with exosomes

March 22, 2011

New work with exosomes promises wide-ranging advances in medicine, courtesy of an emerging biomolecular nanotechnology. As pharmaceutical chemists know, the blood-brain barrier blocks delivery of many molecules that do wonderful things if injected directly into the brain, but injecting the brain isn’t quite as convenient as injecting a vein. Exosomes are lipid vesicles manufactured by […]

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3D atomic imaging of nanoparticles
— a new technique

February 24, 2011

Image and atomic reconstruction From the abstract: Although atomic-resolution electron microscopy has been feasible for nearly four decades, neither electron tomography nor any other experimental technique has yet demonstrated atomic resolution in three dimensions. Here we report the 3D reconstruction of a complex crystalline nanoparticle at atomic resolution. To achieve this, we combined aberration-corrected scanning […]

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