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Foldamers: Accomplishments and Goals

June 1, 2010

As regular readers know, I see foldamer engineering as a key to next-generation atomically precise nanosystems. Valuable in themselves, foldamers can also serve as components of composite systems that exploit diverse materials and nanotechnologies of qualitatively different kinds.
“Foldamers: Accomplishments and Goals”, by Samuel Gellman, heads a collection of 59 abstracts from [...]

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A programmable nanoscale assembly line

May 20, 2010

When I picked up my copy of this week’s Chemical & Engineering News this evening, I found that the lead article begins with this:
Futuristic visions of nanobots that travel the body to treat disease and construct compounds one atom at a time got a little closer to reality this week, thanks to two advances in [...]

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Peptoid nanosheets:
A platform for new nanotechnologies

April 22, 2010

Fresh from Ron Zuckerman’s lab at the Molecular Foundry: a new kind of molecular membrane — thin and crystalline — made by self-assembly of peptoid oligomers. As I discussed in an earlier post, peptoids have remarkable potential as building blocks for self-assembled nanosystems. Peptoids are peptide-like structures, but with monomers that can be chosen from [...]

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Zinc fingers for gripping DNA

April 16, 2010

Zinc finger technology has great promise in genetic engineering and therapeutics, with potential applications in structural DNA nanotechnology, too.
Zinc finger proteins (ZFPs) are often called “game changing” because of the unprecedented way they precisely modify genes. Excitement about them is mirrored in the number of related scientific publications, which have climbed from hardly any 20 [...]

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The molecular approach
to atomically precise fabrication

March 12, 2010

A few days ago, I wrote a brief sketch of the status and paths forward in the molecular approach to atomically precise fabrication. It offers a sampling, not a full picture:

 

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Ribo-Q1: Genetic manufacturing expanded

March 1, 2010

All ribosomes read genetic data as three-letter words that encode 20 standard amino acids (give or take a few anomalies). This is equally true of the ribosomes in deep-sea bacteria living at 120°C, and the ones in your thumb. This universal code has been a wall that bounds the scope of biosynthetic polypeptide engineering — [...]

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Cell-free synthetic biology

February 12, 2010

Synthetic biology doesn’t require cells, and in several ways, cells are liabilities.
Cells can make engineering difficult. Cell membranes and bacterial walls stand between new genes and the machinery needed to transcribe and translate them. They are barriers to liberating gene products. They contain systems that are complex products of eons of evolutionary history, not systems [...]

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Exploiting strong, covalent bonds
for self assembly of robust nanosystems

February 6, 2010

Atomically precise self-assembly of complex structures can be engineered by providing for multiple binding interactions that

Cooperate to stabilize the correct configuration, in a thermodynamic sense, and

Do not stabilize any other configuration, in a kinetic sense

Roughly speaking, in the correct configuration, the parts fit together to allow all the binding interactions to operate simultaneously, and the [...]

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Self assembly and nanomachines:
Complexity, motion, and computational control

January 28, 2010

A commenter on the previous post raised several important issues, and my reply grew into this post. The comment is here, and my reply follows:

 

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Self-assembling nanostructures:
Building the building blocks

January 25, 2010

A set of interrelated advances in chemistry holds great promise for advancing the art of atomically precise fabrication. In this post, I’ll describe an emerging class of modular synthesis methods for making a diverse set of small, complex molecular building blocks.
The road to complex self-assembled nanosystems starts with stable molecular building blocks, and the more [...]

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Boronate esters, Suzuki coupling,
self-assembly, design software, etc.

January 24, 2010

I’ve been exploring some recent developments in chemical synthesis and self-assembly that suggest attractive possibilities for engineering robust self-assembling molecular systems. Boronate esters are involved in two ways.
Two days ago, I sat down to write about this, but then I read further into the literature, and learned substantially more. Yesterday, another cycle of the [...]

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Templates for atomically precise
metal-oxide nanostructures

January 13, 2010

The cover of Science features atomically precise inorganic nanostructures, polyoxometalates (POMs), that form by means of atomically precise templates. The outer rings of these structures contain 150 molybdenum atoms.
POMs are a diverse class of nanoscale metal-oxide structures with characteristics that make them remarkably attractive as potential components for self-assembled composite nanosystems.
These characteristics include:

Atomically precise [...]

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