From the category archives:

Software technologies

The 7th Peptoid Summit:
Progress in peptoid toolkit development

August 13, 2010

The 7th Peptoid Summit highlighted progress in design technology for one of the most promising toolkits in modular molecular systems engineering.
I’ve outlined the submonomer method for peptoid synthesis as a powerful and convenient way to assemble diverse molecular components, and the recent development of crystalline peptoid nanosheets as a platform for extended atomically-precise structures. The [...]

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Needless Megadeaths:
A Suggestion for Science in the Public Interest

June 16, 2010

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How many minds produce knowledge
(and how they don’t)

December 11, 2009

A review of Infotopia
I’ve been discussing problems with public information and ways to improve it with Michael Nielsen, and on this topic, he recommended Infotopia: how many minds produce knowledge by Cass Sunstein. Having just finished reading it, I recommend it too.
With a solid grounding in experiments and studies of group behavior (and enlightened common [...]

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Cybersecurity: Let’s try something that can work

November 25, 2009

William Wulf and Anita Jones have written a brief, tantalizing, and important article in Science: “Reflections on Cybersecurity”. They point the way out of a tangle of security problems (not all, of course) that costs billions of dollars in losses billions in countermeasures, and billions more in opportunity costs — some known and some [...]

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Quantum Computing:
Sorry, no speedup in solving linear systems

November 10, 2009

In the science press, Big News often turns out to be hyped trivia, but the current Big News in quantum computing is something else — a self-hyping mutant of genuine big news, the discovery of an algorithm that promises exponential speedup in a class of problems where the result depends on the solution to a [...]

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Total Recall:
How the E-Memory Revolution Will Change Everything

September 20, 2009

Gordon Bell, a long-time leader and innovator in the world of computation, has immersed himself in a life-changing experiment. Bits and pieces of news about it have been circulating for years, and his new book, just published, gives a full picture. In brief, Gordon records and indexes what he sees, hears, and more — [...]

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Slides for Talk on Nanotechnology
and Computational Challenges

July 28, 2009

I’ve posted the slides for my WORLDCOMP’09 keynote, “Advanced Nanotechnology: Advanced Computing on the Critical Path”: Click here to download.
My earlier talk for the 2009 Berkeley Nanotechnology Forum was directed to a non-specialized nanotechnology audience and surveyed near-term directions in framework-directed self assembly as a basis for next-generation nanosystems. The WORLDCOMP’09 talk is organized like [...]

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Macromolecular Modeling
for Molecular Systems Engineering

April 16, 2009

Nir London of the Macromolecular Modeling Blog has invited me to offer my perspective on the field. After patiently waiting for me to complete it, he’s posted the resulting essay, which I have cross-posted below.
The Macromolecular Modeling Blog is hosted by the Rosetta Design Group, which offers molecular modeling services based on the Rosetta protein [...]

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CAD for Nanoengineering: Atoms, materials, and nanostructures

March 9, 2009

Computer-aided design of structures on an ordinary scale can ignore atoms, and this is a major simplification. A piece of steel, for example, can typically be treated as a homogenous and isotropic material. The dimensions and angles of a steel component can be chosen freely: With few limitations, a steel plate can be of any [...]

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Making vs. Modeling:
A paradox of progress in nanotechnology

February 25, 2009

Knowledge and know-how often go together. Where technologies are concerned, we tend to understand the things we make, and often can make the things we understand. This is a widespread pattern, but it’s important to recognize the exceptions, and nanofabrication is one of them.
There’s no necessary connection between understanding something and being able to make [...]

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Design Software for Atomically Precise Nanotechnologies

February 23, 2009

Design software is arguably the chief limiting factor in the rate of progress toward advanced nanotechnologies, and this makes it a topic of central importance. Questions of design and modeling also touch on diverse topics: technology objectives, scientific knowledge and unknowns, research directions that deserve many millions of dollars of funding, and specific problems that [...]

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Advanced Nanotechnology Keynote

for WORLDCOMP’09

February 17, 2009

I’ll be giving a keynote talk for the opening plenary session of WORLDCOMP’09, the 2009 World Congress in Computer Science, Computer Engineering, and Applied Computing. The conference, to be held July 13–16 in Las Vegas, is the largest annual gathering of researchers in computer science, computer engineering and applied computing.
In my keynote, I’ll describe critical [...]

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