Posts tagged as:

bionanotechnology

“There’s Plenty of Room at the Bottom”
(Richard Feynman, Pasadena, 29 December 1959)

December 29, 2009

“Feynman’s 1959 talk, entitled ‘There’s Plenty of Room at the Bottom’”, was delivered 50 years ago today, and the words I’ve quoted above are the first words in the first sentence of the first paper I wrote, almost 30 years ago, on what later became known as “nanotechnology”. Feynman read and discussed the paper with [...]

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The Molecular Machine Path
to Molecular Manufacturing (1):
Foldamers and Brownian Assembly

December 25, 2009

Part 3 of a series prompted by the upcoming 50th anniversary of Feynman’s historic talk, “There’s Plenty of Room at the Bottom”.

Lathe, 1911 A machine tool, used to make machines

In my view, the most attractive way forward in developing advanced molecular machine systems is by exploiting the molecular machine systems that are available today. Historically, [...]

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How to make carbon nanotubes
at room temperature

November 15, 2009

As I noted in a recent post on self-assembled nanoelectronics (“Carbon Nanotube Transistors through DNA Origami”), carbon nanotubes (CNTs) hold promise for self-assembled nanomechanical systems, too: They are orders of magnitude stiffer than biomolecules, and can serve not only as rigid components, but also as low-friction linear and rotary bearings to support moving parts.
Recent [...]

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Molecular Nanomachines: Physical Principles and Implementation Strategies

October 1, 2009

I’ve migrated another paper to E-drexler.com:

Drexler, KE. “Molecular Nanomachines: Physical Principles and Implementation Strategies”, Annual Review of Biophysics and Biomolecular Structure, 23:377-405 (1994).
(With thanks to Robert Bradbury for the original HTML conversion.)

Click to read.

See also:

The Physical Basis of Atomically Precise Manufacturing
A Telescope Aimed at the Future
Productive nanosystems: the physics of molecular fabrication [pdf] (from [...]

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Carbon Nanotubes in Ordered DNA Wrappers

July 12, 2009

Single-walled carbon nanotubes (SWCNs) are well known for their outstanding strength, stiffness, and electronic properties, but their utility has been limited by the diversity of their structures and the difficulty of separating different kinds. In a new paper in Nature, a DuPont group reports the development of a new method for separation, one that also [...]

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A Third Revolution in DNA Nanotechnology

May 22, 2009

In a new paper, Shawn Douglas and his colleagues at William Shih’s lab have demonstrated the first systematic method for building multilayer 3D nanostructures of DNA. In his commentary, Tom LaBean calls this “a third revolution in DNA nanotechnology”, following Seeman’s launch of the field and Rothemund’s development of the breakthrough origami technique.
In the authors’ [...]

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A DNA Origami Box

May 10, 2009

A paper in the current issue of Nature reports the fabrication of DNA origami boxes ~35 nm on a side; to my knowledge, these are the first closed structures made by these means.
Paul Rothemund’s initial 2006 Nature article [pdf] described a methodical way to form patterns of raised features on origami, based on a raster [...]

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Slides for Berkeley Talk
on Molecular Nanosystems

May 6, 2009

Framework-directed self assembly
I’ve now posted the slides for my Berkeley talk on objectives and experimental directions in biomolecular/inorganic composite nanosystems: Click here to download.
The talk was a keynote at the 2009 Berkeley Nanotechnology Forum.
I’ve described some of the concepts and motivations in an earlier post, and this technology direction is also discussed in the report [...]

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Machines Evolving to the Brink of Failure

April 30, 2009

While writing a post on molecular engineering for the Macromolecular Modeling Blog, I came across an EMBO Reports paper that provided new guidelines for protein engineering; It also illustrates a general principle that should be taken to heart by anyone thinking about molecular engineering from a biomolecular perspective:
Molecular machines tend to evolve toward the [...]

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Earth Day 1970,
and a high road down to molecules

April 23, 2009

I had read Silent Spring before the first Earth Day (now 39 years ago), and I recall telling my classmates that it seemed like a bad idea to spread persistent poisons all over the landscape of a finite world. I was 14, living in a small college town in Oregon.
I read The Limits to Growth [...]

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Macromolecular Modeling
for Molecular Systems Engineering

April 16, 2009

Nir London of the Macromolecular Modeling Blog has invited me to offer my perspective on the field. After patiently waiting for me to complete it, he’s posted the resulting essay, which I have cross-posted below.
The Macromolecular Modeling Blog is hosted by the Rosetta Design Group, which offers molecular modeling services based on the Rosetta protein [...]

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A Revolution
in de novo Protein Engineering Methodology

March 30, 2009

In a recent Nature article, researchers describe the design of a peptide foldamer device (a.k.a. “protein”) that binds and releases oxygen in a way that resembles the heme protein, neuroglobin — and they focus more on the design process than on the design product. They advocate an engineering approach that explicitly rejects aspects of the [...]

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